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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE4D All Species: 11.82
Human Site: S139 Identified Species: 28.89
UniProt: Q08499 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q08499 NP_001098101.1 809 91115 S139 H R P G L K K S R M S W P S S
Chimpanzee Pan troglodytes XP_001138439 809 91104 S139 H R P G L K K S R M S W P S S
Rhesus Macaque Macaca mulatta XP_001101097 595 67340
Dog Lupus familis XP_544349 792 88684 Q122 P L C F K S M Q G L Y S L G V
Cat Felis silvestris
Mouse Mus musculus Q01063 747 84544 S113 D P M T S P G S G L I L Q A N
Rat Rattus norvegicus P14270 803 90534 S134 H R P G L K K S R M S W P S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001086133 721 82347 P87 C F D V E N G P T P G R S P L
Zebra Danio Brachydanio rerio XP_695374 745 84839 L111 R S D S D Y D L S P K S M S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P12252 1070 115060 F386 S D S D L F G F D V E N G Q G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22000 674 75370 T40 H L H N F F R T S S P S A S S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 67.8 84 N.A. 83.5 97 N.A. N.A. N.A. 65 75.7 N.A. 42.1 N.A. 44.8 N.A.
Protein Similarity: 100 99.6 70.2 86.1 N.A. 86.1 97.5 N.A. N.A. N.A. 75.2 81.2 N.A. 53.5 N.A. 59.5 N.A.
P-Site Identity: 100 100 0 0 N.A. 6.6 100 N.A. N.A. N.A. 0 6.6 N.A. 6.6 N.A. 20 N.A.
P-Site Similarity: 100 100 0 6.6 N.A. 26.6 100 N.A. N.A. N.A. 0 6.6 N.A. 13.3 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 10 10 0 % A
% Cys: 10 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 10 20 10 10 0 10 0 10 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % E
% Phe: 0 10 0 10 10 20 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 30 0 0 30 0 20 0 10 0 10 10 10 % G
% His: 40 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % I
% Lys: 0 0 0 0 10 30 30 0 0 0 10 0 0 0 0 % K
% Leu: 0 20 0 0 40 0 0 10 0 20 0 10 10 0 10 % L
% Met: 0 0 10 0 0 0 10 0 0 30 0 0 10 0 0 % M
% Asn: 0 0 0 10 0 10 0 0 0 0 0 10 0 0 10 % N
% Pro: 10 10 30 0 0 10 0 10 0 20 10 0 30 10 0 % P
% Gln: 0 0 0 0 0 0 0 10 0 0 0 0 10 10 0 % Q
% Arg: 10 30 0 0 0 0 10 0 30 0 0 10 0 0 10 % R
% Ser: 10 10 10 10 10 10 0 40 20 10 30 30 10 50 40 % S
% Thr: 0 0 0 10 0 0 0 10 10 0 0 0 0 0 0 % T
% Val: 0 0 0 10 0 0 0 0 0 10 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 30 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _